Microdosing, & silicon-valley
Leo Hollister's
five criteria for establishing that (IF) a drug is hallucinogenic are as follows: https://en.wikipedia.org/wiki/Hallucinogen#Taxonomy (look end of page)
five criteria for establishing that (IF) a drug is hallucinogenic are as follows: https://en.wikipedia.org/wiki/Hallucinogen#Taxonomy (look end of page)
https://money.cnn.com/2015/01/25/technology/lsd-psychedelics-silicon-valley/index.html
Herbert, who works at Cisco, has been in the tech sphere for decades. For him, geek-dom and psychedelics have intersected since the start of his adult life: The first LSD he took was created in an M.I.T. lab at and consumed at a science fiction convention.
In Silicon Valley, there is a premium on creativity, and tools thought to induce or enhance it are avidly sought. Some view psychedelics as a weapon in the arsenal, a way to approach problems differently.
There's no definitive scientific evidence that LSD or other hallucinogens improve creativity, and the DEA classifies LSD as a "highly addictive", "Schedule I drug"
- in truth, hallucinogens actually are used to cure addictions and to be defined as "hallucinogen / psychedelics " the substance can not be addictive by defination accepted by DEA high end gov scientists. So there is a slight issue to fix in Law aria and investigate, who have been these forces who have systematically mislead humans about natuarally needed substances like psychedelics - and for what cause/reason.
Is known, that Soviet Union International Forces have been strongly against psychedelics and eliminated any kind of reasonable information about these cultures and practises physically and from literature. Might be becuse hallucinogen have self realization and truth serium kind of effect besides being able to decode information more deeper and connect dots that common mind would not be able for working/thinking "too fast".
- this is what is my personal logical view on it.
https://www.amazon.com/Shamans-Coat-Native-History-Siberia/dp/0802713998
(Or perhaps, they just wanted to keep their Two-Head-Eagle advantage...)
But at no cost i would reccomend any kind of spirit or ritual things with out deeper knowings..., ordinary christian prayer or at least light meditation is sufficient for ordinary trips when You beginner (most likelly if You read it...), understanding the excistance of Creator helps a lot also when one plan to go "deeper" (more then 125ug ordinary amount).
In truth there is hard to imagine what kind of preperation would help at all when You trully in a 300ug+ level. Most You have read (good and useless) will sound like joke then compared to amazement. But just,please, do it on the ground first, outside city if possile...if not then better lock yourself in a room and just lay down eyes closed if You can! Prepare before fruits, clean a room and take a shower (or You might feel urgent need to do it when on journy.. )
There might be any kind of melting but also might be just complete clear mind.. depens.. but all these experiences seem to be needed.
Eventiually that will be like like having new skill. Directions where to go with it is many, and the not so random and uncontrollable all... but also at nocost try Not to be "in controll" or You might miss the mainpoints, trust and learning.
Magic muhrooms (1.st class) are also compete safe to give to kids.
Their brain is able to take it more naturally and with less strugle, andmore early they lear - more larger the canche is that this person will newer smoke, drinkn or be violent to a life.
English is not my language, i nearly newer learn that, so i hope, my text was understandable, and i will be happy if You can send me even on comments, the correct senteces of my story.
----
There is another complete safe way:
https://en.wikipedia.org/wiki/Microdosing
In Silicon Valley, there is a premium on creativity, and tools thought to induce or enhance it are avidly sought. Some view psychedelics as a weapon in the arsenal, a way to approach problems differently.
There's no definitive scientific evidence that LSD or other hallucinogens improve creativity, and the DEA classifies LSD as a "highly addictive", "Schedule I drug"
- in truth, hallucinogens actually are used to cure addictions and to be defined as "hallucinogen / psychedelics " the substance can not be addictive by defination accepted by DEA high end gov scientists. So there is a slight issue to fix in Law aria and investigate, who have been these forces who have systematically mislead humans about natuarally needed substances like psychedelics - and for what cause/reason.
Is known, that Soviet Union International Forces have been strongly against psychedelics and eliminated any kind of reasonable information about these cultures and practises physically and from literature. Might be becuse hallucinogen have self realization and truth serium kind of effect besides being able to decode information more deeper and connect dots that common mind would not be able for working/thinking "too fast".
- this is what is my personal logical view on it.
https://www.amazon.com/Shamans-Coat-Native-History-Siberia/dp/0802713998
(Or perhaps, they just wanted to keep their Two-Head-Eagle advantage...)
But at no cost i would reccomend any kind of spirit or ritual things with out deeper knowings..., ordinary christian prayer or at least light meditation is sufficient for ordinary trips when You beginner (most likelly if You read it...), understanding the excistance of Creator helps a lot also when one plan to go "deeper" (more then 125ug ordinary amount).
In truth there is hard to imagine what kind of preperation would help at all when You trully in a 300ug+ level. Most You have read (good and useless) will sound like joke then compared to amazement. But just,please, do it on the ground first, outside city if possile...if not then better lock yourself in a room and just lay down eyes closed if You can! Prepare before fruits, clean a room and take a shower (or You might feel urgent need to do it when on journy.. )
There might be any kind of melting but also might be just complete clear mind.. depens.. but all these experiences seem to be needed.
Eventiually that will be like like having new skill. Directions where to go with it is many, and the not so random and uncontrollable all... but also at nocost try Not to be "in controll" or You might miss the mainpoints, trust and learning.
Magic muhrooms (1.st class) are also compete safe to give to kids.
Their brain is able to take it more naturally and with less strugle, andmore early they lear - more larger the canche is that this person will newer smoke, drinkn or be violent to a life.
English is not my language, i nearly newer learn that, so i hope, my text was understandable, and i will be happy if You can send me even on comments, the correct senteces of my story.
----
There is another complete safe way:
https://en.wikipedia.org/wiki/Microdosing
Microdosing, or micro-dosing, is a technique for studying the behaviour of drugs in humans through the administration of doses so low ("sub-therapeutic") they are unlikely to produce whole-body effects, but high enough to allow the cellular response to be studied. This is called a "Phase 0 study" and is usually conducted before clinical Phase I to predict whether a drug is viable for the next phase of testing. Human microdosing aims to reduce the resources spent on non-viable drugs and the amount of testing done on animals.
Less commonly, the term "microdosing" is also sometimes used to refer to precise dispensing of small amounts of a drug substance (e.g., a powder API) for a drug product (e.g., a capsule),[1] and when the drug substance also happens to be liquid this can potentially overlap what is termed microdispensing. For example, psychedelic microdosing.[2]
Techniques
The basic approach is to label a candidate drug using the radioisotope carbon-14,[citation needed] then administer the compound to human volunteers at levels typically about 100 times lower than the proposed therapeutic dosage (from around 1 to 100 micrograms but not above).[3]
As only microdose levels of the drug are used, analytical methods are limited. Extreme sensitivity is needed. Accelerator Mass Spectrometry is the most common method for microdose analysis. AMS was developed in the late 1970s from two distinct research threads with a common goal:[citation needed] an improvement in radiocarbon dating that would make efficient use of datable material and that would extend the routine and maximum reach of radiocarbon dating. AMS is routinely used in geochronology and archaeology, but biological applications began appearing in 1990 mainly due to the work of scientists at Lawrence Livermore National Laboratory. AMS service is now more accessible for biochemical quantitation from several private companies and non-commercial access to AMS is available at the National Institutes of Health (NIH) Research Resource at Lawrence Livermore National Laboratory, or through the development of smaller affordable spectrometers. AMS does not measure the radioactivity of carbon-14 in microdose samples. AMS, like other mass spectrometry methods, measures ionic species according to mass-to-charge ratio.
Impact of use
It is reported that 15 of the 20 largest pharmaceutical companies have now used microdosing in drug development, and the use of the technique has been provisionally endorsed by both the European Medicines Agency and the Food and Drug Administration. It was once expected that by 2010, human microdosing would have gained a secure foothold at the discovery-preclinical interface, driven by early measurement of candidate drug behavior in humans and by irrefutable economic arguments.
In January 2006, the European Union Microdose AMS Partnership Programme (EUMAPP) was launched. Ten organizations from five different countries (United Kingdom, Sweden, Netherlands, France, and Poland) will study various approaches to the basic AMS technique. The study is set to be published in 2009.
One of the most meaningful potential outcomes of Phase-0/Microdosing studies is the early termination of development. In 2017, Okour et al published the first example in literature of a termination of an oral drug based on IV microdose data.[4] This study provides an example of the application of microdosing in circumstances where pre-clinical data were not sufficient to provide accurate information to guide first-in-human (FIH) study design.
References
^ Tablets & Capsules, March 2009. "Micro-dosing equipment fills niche in R&D, clinical trial materials".
^ "Everything You Wanted to Know About Microdosing (But Were Afraid to Ask)". The Huffington Post. 13 January 2016.
^ [1] Animal Testing Perspectives: Microdosing
^ Okour, Malek; Derimanov, Geo; Barnett, Rodger; Fernandez, Esther; Ferrer, Santiago; Gresham, Stephanie; Hossain, Mohammad; Gamo, Francisco-Javier; Koh, Gavin; Pereira, Adrian; Rolfe, Katie; Wong, Deborah; Young, Graeme; Rami, Harshad; Haselden, John (2018). "A human microdose study of the antimalarial drug GSK3191607 in healthy volunteers". British Journal of Clinical Pharmacology. 84 (3): 482–489. doi:10.1111/bcp.13476. PMC 5809343. PMID 29168205.
- "The use of accelerator mass spectrometry to obtain early human ADME/PK data" G Lappin & R C Garner Expert Opinion in Pug Metabolite and Toxic (2005) 1(1):23-31
- "Improved early clinical development through human microdosing studies" I Wilding & J Bell Drug Discovery Today 2005 July 1;10(13):890-4
- "New ultrasensitive detection technologies and techniques for use in microdosing studies" G Lappin, C Wagner, O Langer & N van de Merbel Bioanalysis 2009 May 1(2):357–366 doi:10.4155/bio.09.40
External links
Review article on microdosing as a means of reducing the use of animals in drug testing (PDF format)
EU announcement of EUMAPP project
PS: Important to know:
Psychedelic have nothing much common with the ordinary "drugs" that one is labeled as. In many situations it is actually like anti-drug and can make sober person much more sober and more near to family, work and home.
There is medical classification and Law related casification - the later one is not based on science but politics.
( UK's Dr. https://www.youtube.com/watch?v=bCChf2WHNE4 short intro about that ).
https://en.wikipedia.org/wiki/Hallucinogen
"The word psychedelic (From Ancient Greek ψυχή (psychê) mind, soul + δηλος (dêlos) manifest, reveal + -ic) was coined to express the idea of a drug that makes manifest a hidden but real aspect of the mind. It is commonly applied to any drug with perception-altering effects such as LSD and other ergotamine derivatives, DMT and other tryptamines including the alkaloids of Psilocybe spp., mescaline and other phenethylamines."
The term "psychedelic" is applied somewhat interchangeably with "psychotomimetic" and "hallucinogen",[1] The classical hallucinogens are considered to be the representative psychedelics and LSD is generally considered the prototypical psychedelic
Psychedelic have nothing much common with the ordinary "drugs" that one is labeled as. In many situations it is actually like anti-drug and can make sober person much more sober and more near to family, work and home.
There is medical classification and Law related casification - the later one is not based on science but politics.
( UK's Dr. https://www.youtube.com/watch?v=bCChf2WHNE4 short intro about that ).
https://en.wikipedia.org/wiki/Hallucinogen
"The word psychedelic (From Ancient Greek ψυχή (psychê) mind, soul + δηλος (dêlos) manifest, reveal + -ic) was coined to express the idea of a drug that makes manifest a hidden but real aspect of the mind. It is commonly applied to any drug with perception-altering effects such as LSD and other ergotamine derivatives, DMT and other tryptamines including the alkaloids of Psilocybe spp., mescaline and other phenethylamines."
The term "psychedelic" is applied somewhat interchangeably with "psychotomimetic" and "hallucinogen",[1] The classical hallucinogens are considered to be the representative psychedelics and LSD is generally considered the prototypical psychedelic
Psychedelics are a class of drug whose primary action is to trigger psychedelic experiences via serotonin receptor agonism,[2] causing thought and visual/auditory changes, and altered state of consciousness.[3] Major psychedelic drugs include mescaline, LSD, psilocybin, marijuana (Tetrahydracannabinol), DMT. Studies show that psychedelics are physiologically safe and do not lead to addiction.[4] Studies conducted using psilocybin, marijuana in a psychotheraputic setting reveal that psychedelic drugs may assist with treating alcohol and nicotine addiction.[5]
"The classical hallucinogens are agents that meet Hollister's original definition, but are also agents that: (a) bind at 5-HT2 serotonin receptors, and (b) are recognized by animals trained to discriminate 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from vehicle.[2]
// Before censor.
Leo Hollister's
five criteria for establishing that a drug is hallucinogenic are as follows:https://en.wikipedia.org/wiki/Hallucinogen#Taxonomy
five criteria for establishing that a drug is hallucinogenic are as follows:https://en.wikipedia.org/wiki/Hallucinogen#Taxonomy
National Institute on Drug Abuse (https://www.drugabuse.gov) :
https://erowid.org/culture/characters/shulgin_alexander/shulgin_alexander.shtml
Full Doc where Hollister is pointed out as with best defination: https://web.archive.org/web/20150723031539/http://archives.drugabuse.gov/pdf/monographs/146.pdf
Full Doc where Hollister is pointed out as with best defination: https://web.archive.org/web/20150723031539/http://archives.drugabuse.gov/pdf/monographs/146.pdf
Truth is around us, we just must make effort to find it.
